ABSTRACT
Objective@#To investigate the application effects of prednisone combined with indomethacin in the treatment of patients with subacute thyroiditis.@*Methods@#From January 2015 to January 2017, 140 patients with subacute thyroiditis in Yantai Mountain Hospitalwere chosen in this research, and they were randomly divided into control group and research group according to the digital table, with 70 cases in each group.Both two groups were treated with prednisone, the research group was given indomethacin on this basis.The time of fever extinction, the time of goiter subside, the time of thyroid ache extinction, ESR, thyroid hormone, adverse reaction and recurrence of the two groups were compared.@*Results@#The time of fever extinction, the time of goiter subside, the time of thyroid ache extinction of the research group were (1.65±0.89)d, (2.54±0.92)d, (7.63±1.57)d, which were all shorter than those of the control group [(2.07±1.03)d, (2.96±1.35)d, (8.45±1.84)d], the differences were statistically significant(t=2.581, 2.151, 2.836, all P<0.05). After treatmnet, ESR, TSH, FT3, FT4 of the research group were (9.35±4.17)mm/h, (2.53±2.07)μU/L, (5.37±2.81)pmol/L, (14.26±2.54)pmol/L, respectively, which of the control group were (9.67±4.26)mm/h, (2.45±1.84)μU/L, (5.49±2.23)pmol/L, (14.85±3.27)pmol/L, respectively, there were no statistically significant differences between the two groups (all P>0.05). There were 6 cases(8.57%) occurred adverse reaction in the research group, and 15 cases(21.42%) in the control group, the difference was statistically significant(χ2=4.538, P<0.05). All the patients were followed up for 6 months, 6 cases(8.57%) of recrudescence occurred in research group, 7 cases(10.00%) in the control group, the difference was not statistically significant (χ2=0.085, P>0.05).@*Conclusion@#Prednisone combined with indomethacin has similar effects as prednisone in the treatment of patients with subacute thyroiditis, but the combination has faster improvement of improving fever, pain, swelling, etc, and with better safety.